We have undertaken the Neuroscience Monoclonal Antibody Sequencing Initiative (NeuroMabSeq),
a concerted effort to determine and make publicly available the sequences of monoclonal antibodies
valuable to neuroscience research.
We previously created a valuable collection of mouse monoclonal antibodies (mAbs) validated for
neuroscience research. As part of a BRAIN Initiative project (NIH U24 NS109113) to enhance dissemination and utility
of this valuable resource, we are applying high-throughput DNA sequencing technologies to determine
the sequence of the immunoglobulin heavy and light chain variable domains from our collection of
hybridoma cells that are the source of these mAbs.
These efforts will allow for permanent archiving of this valuable collection as DNA sequence.
The availability of these sequences will also allow researchers to generate plasmids for expression
of molecularly defined mAbs, leading to enhanced research transparency and reproducibility.
This will also allow for engineering of these antibodies into alternate forms including single
chain variable fragments or ScFvs.
This website serves as the public DNA sequence repository for the sequences of these mouse mAb heavy and
light chain variable domains and serves as an open resource for enhancing dissemination of this
valuable collection of validated mAbs.
Disclaimer: The posted sequences are provided “as-is” and without warranty, and are for research use only.
|Total Mouse mAb Sequence Entries in Database:
||Total Mouse Heavy Chain Sequences:
||Total Mouse Light Chain Sequences