NeuroMabSeq

Mouse Light Chain Results

Sequence: 1 -- Star rating: ☆4.00

GAGCCACACAAACTCAGGGAAAGCTCGAAGATGGTTTTCACACCTCAGATACTTGGACTTATGCTTTTTTGGATTTCAGCCTCCAGAGGTGATTTTGTGCTGACTCAGTCTCCTGCCACCCTGTCTGTGACTCCAGGAGATAGCGTCAGTCTTTCCTGCAGGGCCAGCCAAAGTTTTCGCAACAACCTACACTGGTATCAACAAAAATCACATGAGTCTCCAGGACTTCTCATCAAGTATGCTTCCCAGTCCATGTCTGGGATCCCCTCCAGGTTCAGTGGCAGTGGATCAGGGACAGATTTCACTCTCAGTATCAACAGTGTGGAGACTGAAGATTTTGGAATGTGTTTCTGTCAACAGACTAACACCTGGCCGTGGACGTTCGGTGGAGGCACCAAGCTGGAAATCAAGCGGGCT

Sequence 1 corresponding to IMGT amino acids 1-127:

GATTTTGTGCTGACTCAGTCTCCTGCCACCCTGTCTGTGACTCCAGGAGATAGCGTCAGTCTTTCCTGCAGGGCCAGCCAAAGTTTTCGCAACAACCTACACTGGTATCAACAAAAATCACATGAGTCTCCAGGACTTCTCATCAAGTATGCTTCCCAGTCCATGTCTGGGATCCCCTCCAGGTTCAGTGGCAGTGGATCAGGGACAGATTTCACTCTCAGTATCAACAGTGTGGAGACTGAAGATTTTGGAATGTGTTTCTGTCAACAGACTAACACCTGGCCGTGGACGTTCGGTGGAGGCACCAAGCTGGAAATCAAG

Sequencing Info ☆ Scoring Info Amino Acid Information Blat Sequence

IMGT amino acid positions:

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107	108	109	110	111	112	113	114	115	116	117	118	119	120	121	122	123	124	125	126	127
D	F	V	L	T	Q	S	P	A	T	L	S	V	T	P	G	D	S	V	S	L	S	C	R	A	S	Q	S	F	-	-	-	-	-	-	R	N	N	L	H	W	Y	Q	Q	K	S	H	E	S	P	G	L	L	I	K	Y	A	-	-	-	-	-	-	-	S	Q	S	M	S	G	I	P	-	S	R	F	S	G	S	G	-	-	S	G	T	D	F	T	L	S	I	N	S	V	E	T	E	D	F	G	M	C	F	C	Q	Q	T	N	T	-	-	-	-	W	P	W	T	F	G	G	G	T	K	L	E	I	K
LFR1																										CDR-L1												LFR2																	CDR-L2										LFR3																																							CDR-L3													LFR4

Residues	Region	Sequence Fragment	Length	Max Index Range
1-26	LFR1	DFVLTQSPATLSVTPGDSVSLSCRAS	26	26
27-38	CDR-L1	QSFRNN	6	12
39-55	LFR2	LHWYQQKSHESPGLLIK	17	17
56-65	CDR-L2	YAS	3	10
66-104	LFR3	QSMSGIPSRFSGSGSGTDFTLSINSVETEDFGMCFC	36	39
105-117	CDR-L3	QQTNTWPWT	9	13
118-128	LFR4	FGGGTKLEIK	10	10

Sequence: 2 -- Star rating: ☆3.98

ACTCAAGACTTTTTGTATCAAGTTCTCAGAATGAGGTGCCTAGCTGAGTTCCTGGGGCTGCTTGTGCTCTGGATCCCTGGAGCCTTTGGGGATGTTGTGATGACTCAGGCTGCACCCTCTGTAACTGTCACTCCTGGAGAGTCAGTATCCATCTCCTGCAGGTCTAGTAAGAGTCTCCTGCATAGTAATGGCAACACTTACTTGTATTGGTTCCTGCAGAGGCCAGGCCAGTCTCCTCAACTCCTGATATATCGGATGTCCAACCTTGCCTCAGGAGTCCCAGACAGGTTCAGTGGCAGTGGGTCAGGAACTGCTTTCACACTGAGAATCAGTAGAGTGGAGGCTGAGGATGTGGGTGTTTATTACTGTATGCAACATCTAGAATATCCGCTCACGTTCGGTGCGGGGACCAAGCTGGAGCTGAAACGGGCT

Sequence 2 corresponding to IMGT amino acids 1-127:

GATGTTGTGATGACTCAGGCTGCACCCTCTGTAACTGTCACTCCTGGAGAGTCAGTATCCATCTCCTGCAGGTCTAGTAAGAGTCTCCTGCATAGTAATGGCAACACTTACTTGTATTGGTTCCTGCAGAGGCCAGGCCAGTCTCCTCAACTCCTGATATATCGGATGTCCAACCTTGCCTCAGGAGTCCCAGACAGGTTCAGTGGCAGTGGGTCAGGAACTGCTTTCACACTGAGAATCAGTAGAGTGGAGGCTGAGGATGTGGGTGTTTATTACTGTATGCAACATCTAGAATATCCGCTCACGTTCGGTGCGGGGACCAAGCTGGAGCTGAAA

Sequencing Info ☆ Scoring Info Amino Acid Information Blat Sequence

IMGT amino acid positions:

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107	108	109	110	111	112	113	114	115	116	117	118	119	120	121	122	123	124	125	126	127
D	V	V	M	T	Q	A	A	P	S	V	T	V	T	P	G	E	S	V	S	I	S	C	R	S	S	K	S	L	L	H	S	-	N	G	N	T	Y	L	Y	W	F	L	Q	R	P	G	Q	S	P	Q	L	L	I	Y	R	M	-	-	-	-	-	-	-	S	N	L	A	S	G	V	P	-	D	R	F	S	G	S	G	-	-	S	G	T	A	F	T	L	R	I	S	R	V	E	A	E	D	V	G	V	Y	Y	C	M	Q	H	L	E	-	-	-	-	Y	P	L	T	F	G	A	G	T	K	L	E	L	K
LFR1																										CDR-L1												LFR2																	CDR-L2										LFR3																																							CDR-L3													LFR4

Residues	Region	Sequence Fragment	Length	Max Index Range
1-26	LFR1	DVVMTQAAPSVTVTPGESVSISCRSS	26	26
27-38	CDR-L1	KSLLHSNGNTY	11	12
39-55	LFR2	LYWFLQRPGQSPQLLIY	17	17
56-65	CDR-L2	RMS	3	10
66-104	LFR3	NLASGVPDRFSGSGSGTAFTLRISRVEAEDVGVYYC	36	39
105-117	CDR-L3	MQHLEYPLT	9	13
118-128	LFR4	FGAGTKLELK	10	10

Mouse Heavy Chain Results

Sequence: 1 -- Star rating: ☆4.97

ACATCTCTCTCATTAGAGGTTGATCTTTGAGGAAAACAGGGTGTTGCCTAAAGGATGAAAGTGTTGAGTCTGTTGTACCTGTTGACAGCCATTCCTGGTTTCCTGTCTGAAGTTCAGCTTCAGGAGTCAGGACCTGGCCTCGTGAAACCTTCTCAGTCTCTGTCTCTCACCTGCTCTGTCACTGGCTACTCCATCACCAGTGGTTATTACTGGCTCTGGATTCGGCAACTTCCAGGAAACAAACTGGAATGGTTGGGCTACATAAGCTACGACGGGACCAGTAAGCCCAACCCATCTCTCAAAAATCGACTCTCCATCACTCGTGACACATCTGAGAACCAGTTTTTCCTGAAGTTGAATTCTGTGACTACTGAGGACACAGCTACATATTACTGTGCAAGAGGGGGCTTTTACTGGGGCCAAGGGACTCTGGTCACTGTCTCTGCAG

Sequence 1 corresponding to IMGT amino acids 1-128:

GAAGTTCAGCTTCAGGAGTCAGGACCTGGCCTCGTGAAACCTTCTCAGTCTCTGTCTCTCACCTGCTCTGTCACTGGCTACTCCATCACCAGTGGTTATTACTGGCTCTGGATTCGGCAACTTCCAGGAAACAAACTGGAATGGTTGGGCTACATAAGCTACGACGGGACCAGTAAGCCCAACCCATCTCTCAAAAATCGACTCTCCATCACTCGTGACACATCTGAGAACCAGTTTTTCCTGAAGTTGAATTCTGTGACTACTGAGGACACAGCTACATATTACTGTGCAAGAGGGGGCTTTTACTGGGGCCAAGGGACTCTGGTCACTGTCTCTGCA

Sequencing Info ☆ Scoring Info Amino Acid Information Blat Sequence

IMGT amino acid positions:

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107	108	109	110	111	112	113	114	115	116	117	118	119	120	121	122	123	124	125	126	127	128
E	V	Q	L	Q	E	S	G	P	-	G	L	V	K	P	S	Q	S	L	S	L	T	C	S	V	T	G	Y	S	I	T	-	-	-	S	G	Y	Y	W	L	W	I	R	Q	L	P	G	N	K	L	E	W	L	G	Y	I	S	Y	D	-	-	-	G	T	S	K	P	N	P	S	L	K	-	N	R	L	S	I	T	R	D	T	S	E	N	Q	F	F	L	K	L	N	S	V	T	T	E	D	T	A	T	Y	Y	C	A	R	G	-	-	-	-	-	-	-	G	F	Y	W	G	Q	G	T	L	V	T	V	S	A
HFR1																										CDR-H1												HFR2																	CDR-H2										HFR3																																							CDR-H3													HFR4

Residues	Region	Sequence Fragment	Length	Max Index Range
1-26	HFR1	EVQLQESGPGLVKPSQSLSLTCSVT	25	26
27-38	CDR-H1	GYSITSGYY	9	12
39-55	HFR2	WLWIRQLPGNKLEWLGY	17	17
56-65	CDR-H2	ISYDGTS	7	10
66-104	HFR3	KPNPSLKNRLSITRDTSENQFFLKLNSVTTEDTATYYC	38	39
105-117	CDR-H3	ARGGFY	6	13
118-128	HFR4	WGQGTLVTVSA	11	11

Entry: K69/3.2

Protein Target: Nav1.2 Na+ channel

Category: NeuroMab mAbs

Mouse Light Chain Results

Mouse Heavy Chain Results