NeuroMabSeq

Mouse Light Chain Results

Sequence: 1 -- Star rating: ☆4.17 -- Verified by Cloning: ✅

CTGACCAGTCTCCTAAAGGCGCCTCATCAAAATGAAGCTGCCTGTTCTGCTAGTGGTGCTGCAATTGTTCACGAGTCCAGCCTCAAGCAGTGATGTTGTTCTGACCCAAACTCCACTCTCTCTGCCTGTCAATATTGGAGATCAAGCCTCTATCTCTTGCAAGTCTACTAAGAGTCTTCTGAATAGTGATGGATTCACTTATTTGGACTGGTACCTGCAGAAGCCAGGCCAGTCTCCACAGCTCCTAATATTTTTGGTTTCTGATCGATTTTCTGGAGTTCCAGACAGGTTCAGTGGCAGTGGGTCAGGAACAGATTTCACACTCAAGATCAGCAGAGTGGAGGCTGAGGATTTGGGAGTTTATTATTGCTTCCAGAGTAACTATCTTCCTCTAGGGACGTTCGGTGGAGGCACCAAGCTGGAAATCAAACGGGCT

Sequence 1 corresponding to IMGT amino acids 1-127:

GATGTTGTTCTGACCCAAACTCCACTCTCTCTGCCTGTCAATATTGGAGATCAAGCCTCTATCTCTTGCAAGTCTACTAAGAGTCTTCTGAATAGTGATGGATTCACTTATTTGGACTGGTACCTGCAGAAGCCAGGCCAGTCTCCACAGCTCCTAATATTTTTGGTTTCTGATCGATTTTCTGGAGTTCCAGACAGGTTCAGTGGCAGTGGGTCAGGAACAGATTTCACACTCAAGATCAGCAGAGTGGAGGCTGAGGATTTGGGAGTTTATTATTGCTTCCAGAGTAACTATCTTCCTCTAGGGACGTTCGGTGGAGGCACCAAGCTGGAAATCAAA

Sequencing Info ☆ Scoring Info Amino Acid Information Blat Sequence

IMGT amino acid positions:

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107	108	109	110	111	112	113	114	115	116	117	118	119	120	121	122	123	124	125	126	127
D	V	V	L	T	Q	T	P	L	S	L	P	V	N	I	G	D	Q	A	S	I	S	C	K	S	T	K	S	L	L	N	S	-	D	G	F	T	Y	L	D	W	Y	L	Q	K	P	G	Q	S	P	Q	L	L	I	F	L	V	-	-	-	-	-	-	-	S	D	R	F	S	G	V	P	-	D	R	F	S	G	S	G	-	-	S	G	T	D	F	T	L	K	I	S	R	V	E	A	E	D	L	G	V	Y	Y	C	F	Q	S	N	Y	-	-	-	L	P	L	G	T	F	G	G	G	T	K	L	E	I	K
LFR1																										CDR-L1												LFR2																	CDR-L2										LFR3																																							CDR-L3													LFR4

Residues	Region	Sequence Fragment	Length	Max Index Range
1-26	LFR1	DVVLTQTPLSLPVNIGDQASISCKST	26	26
27-38	CDR-L1	KSLLNSDGFTY	11	12
39-55	LFR2	LDWYLQKPGQSPQLLIF	17	17
56-65	CDR-L2	LVS	3	10
66-104	LFR3	DRFSGVPDRFSGSGSGTDFTLKISRVEAEDLGVYYC	36	39
105-117	CDR-L3	FQSNYLPLGT	10	13
118-128	LFR4	FGGGTKLEIK	10	10

Mouse Heavy Chain Results

Sequence: 1 -- Star rating: ☆4.31 -- Verified by Cloning: ✅

AGCTCTGACAGAGGAGGCCGGTCCTGGATTCGATTCCCAGTTCCTCACATTCAGTCAGCACTGAACACGGACCCCTCACCATGAACTTCGGGCTCAGCTTGATTTTCCTTGCCCTCATTTTAAAAGGTGTCCAGTGTGAGGTGCAGCTGGTGGAGTCTGGGGGAGACTTAGTGAAGCCTGGAGGGTCCCTGAAACTCTCCTGTGCAGCCTCTGGATTCACTTTCAGTAACTATGGCATGTCTTGGGTTCGCCAGACTCCAGACAAGAGGCTGGAGTCGGTCGCAACCATTAGTAGTCGTGGTAGTTACACCTACTATCCAGACAGTGTGAAGGGGCGATTCACCATCTCCAGAGACAATGCCAAGAACACCCTATACCTGCAAATGAGCAGTCTGAAGTCTGACGACACAGCCATGTATTACTGTGCAAGACAGGGGAGAGGCTACTTTGACTACTGGGGCCAAGGCACCACTCTCACAGTCTCCTCAG

Sequence 1 corresponding to IMGT amino acids 1-128:

GAGGTGCAGCTGGTGGAGTCTGGGGGAGACTTAGTGAAGCCTGGAGGGTCCCTGAAACTCTCCTGTGCAGCCTCTGGATTCACTTTCAGTAACTATGGCATGTCTTGGGTTCGCCAGACTCCAGACAAGAGGCTGGAGTCGGTCGCAACCATTAGTAGTCGTGGTAGTTACACCTACTATCCAGACAGTGTGAAGGGGCGATTCACCATCTCCAGAGACAATGCCAAGAACACCCTATACCTGCAAATGAGCAGTCTGAAGTCTGACGACACAGCCATGTATTACTGTGCAAGACAGGGGAGAGGCTACTTTGACTACTGGGGCCAAGGCACCACTCTCACAGTCTCCTCA

Sequencing Info ☆ Scoring Info Amino Acid Information Blat Sequence

IMGT amino acid positions:

1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19	20	21	22	23	24	25	26	27	28	29	30	31	32	33	34	35	36	37	38	39	40	41	42	43	44	45	46	47	48	49	50	51	52	53	54	55	56	57	58	59	60	61	62	63	64	65	66	67	68	69	70	71	72	73	74	75	76	77	78	79	80	81	82	83	84	85	86	87	88	89	90	91	92	93	94	95	96	97	98	99	100	101	102	103	104	105	106	107	108	109	110	111	112	113	114	115	116	117	118	119	120	121	122	123	124	125	126	127	128
E	V	Q	L	V	E	S	G	G	-	D	L	V	K	P	G	G	S	L	K	L	S	C	A	A	S	G	F	T	F	-	-	-	-	S	N	Y	G	M	S	W	V	R	Q	T	P	D	K	R	L	E	S	V	A	T	I	S	S	R	-	-	G	S	Y	T	Y	Y	P	D	S	V	K	-	G	R	F	T	I	S	R	D	N	A	K	N	T	L	Y	L	Q	M	S	S	L	K	S	D	D	T	A	M	Y	Y	C	A	R	Q	G	R	-	-	-	G	Y	F	D	Y	W	G	Q	G	T	T	L	T	V	S	S
HFR1																										CDR-H1												HFR2																	CDR-H2										HFR3																																							CDR-H3													HFR4

Residues	Region	Sequence Fragment	Length	Max Index Range
1-26	HFR1	EVQLVESGGDLVKPGGSLKLSCAAS	25	26
27-38	CDR-H1	GFTFSNYG	8	12
39-55	HFR2	MSWVRQTPDKRLESVAT	17	17
56-65	CDR-H2	ISSRGSYT	8	10
66-104	HFR3	YYPDSVKGRFTISRDNAKNTLYLQMSSLKSDDTAMYYC	38	39
105-117	CDR-H3	ARQGRGYFDY	10	13
118-128	HFR4	WGQGTTLTVSS	11	11

Entry: N255/38.1

Protein Target: Nav1.4 Na+ channel

Category: NeuroMab mAbs

Mouse Light Chain Results

Mouse Heavy Chain Results